Abstract: The process connection between the upstream and downstream of the sour gas field is critical to the safe, high-quality and efficient operation of the gas field. Aiming at the problems caused by a large number of corrosion inhibitors brought into the desulfurization system for a short time during the batch processing of the upstream gas field, such as foaming, liquid flooding of the purification device, the effects of the corrosion inhibitors in the batch processing of the upstream gas field gathering and transportation system on the properties of UDS-2 composite desulfurization solution were analyzed through simulation experiments and investigating field conditions. The results showed that the corrosion inhibitor had a significant contribution to solution foaming, and the surface tension, foam height and defoaming time increased with the increase of corrosion inhibitor content. With the same dose of inhibitor, the foaming height increased with the increase of gas velocity. Under the industrial conditions, by enhancing the filtration of feed gas, adjusting the load parameters, and using the foam inhibiting agent injection system, the operation stability could be effectively improved, and the safe and stable operation of the natural gas desulfurization device was realized under the batch processing condition.