Abstract: Based on the process design data of a high organic sulfur natural gas purification unit, this paper compares and analyzes three kinds of Amine packages, including Amine, DBR Amine and Acid Gas in HYSYS v7.3 and v9.0. The results show that Amine and DBR Amine packages are not suitable for the calculation of high organic sulfur containing gases, and can only be used in single flow path tray. When they are used in packed column, it is necessary to convert into the corresponding actual plate number by experience. The electrolyte NRTL model in Acid Gas package, which appeared after HYSYS v8.3, can be used for calculation of up to 4-flow path tray, various types of packed column, and high organic sulfur containing gas. The results of Kent Eisenberg and Li-Mather models in Amine/DBR Amine are not significantly different from those of Chen model in Acid Gas package, but the range of application of Chen model is larger than that of Kent-Eisenberg and Li-Mather model, which can be used to calculate high organic sulfur system.