Abstract: Based on the chemical reaction calculation and analysis software Chemkin, the thermodynamic equilibrium composition of hydrogen production by partial oxidation reforming of ethanol is analyzed by using Gibbs free energy minimization method. The variation of equilibrium components is calculated under the conditions of temperature from 500 K to 2 000 K, pressure from 50 to 400 kPa and oxygen to alcohol molar ratio from 0 to 2.0. The result of calculations shows that the equilibrium composition is significantly affected by temperature and oxygen to alcohol molar ratio. Under the optimal operating conditions of 1 100 K, 120 kPa, and oxygen to alcohol molar ratio of 0.60, better reforming effects can be obtained.