Abstract: The Lucaogou Formation reservoir of Jimusar shale oil in Xinjiang Oilfield Company has the characteristics of low porosity and low permeability, no developmental edge and bottom water, thin oil layer with well developed bedding plane, and thick oil quality. In the early stage, the open-hole packer completion fracturing technology had realized the new production and high yield of some single wells, but there was a lack of effective refracturing technology for open-hole packer completion horizontal wells. Aiming at the above problems, the research on multi-stage temporary plugging and refracturing technology was carried out. Through the experimental study on the key temporary plugging agent, it was found that the temporary plugging agent A had the advantages of pressure bearing of more than 60 MPa and dissolution rate of less than 3% within 6 days. The field test results of the selected temporary plugging agent A was good, and the oil output of typical well Ji XXX_H after fracturing was 47.5 t per day. This technology breaks the traditional idea that open-hole packer horizontal wells cannot be refractured, and provides a reference for similar reservoirs and similar processes at home and abroad.