Abstract: In view of the disadvantage of traditional shell-tube heat transfer reactor, a new cold plate-heat transfer reactor is designed, which adopts new cold plate to be heat exchange element. This article analyzes velocity field and temperature distribution of catalyst bed and cold liquid inside cold plate by means of numerical simulation, validates heat transfer coefficient and heat transfer performance of new reactor. The results show that liquid flow direction and velocity change constantly which result in aggravation of turbulence effect, breaking stagnation boundary layer and reducing the heat resistance.Comparing with traditional shell-tube heat transfer reactor, the calculated heat transfer coefficient of the cold plate-heat transfer reactor is improved obviously.