Abstract: With the rapid economic development in China, the growing demand for natural gas as a clean energy, natural gas industry has gradually been going into the period of development. Many frontier technologies, such as ionic liquid technology, membrane separation, biological desulfurization, exploit a new way for the existing gas desulfurization technology, and promote existing technology development to the direction of environmental protection, refinement, science and technicalization. However, with the stimulation of the old gas well and development of the new gas fields, the variation of the raw gas components tends to be complicated. To meet the stricter environment standards and energy strategic demands of China, it is urgent to take into deep consideration about research direction and development of natural gas purification technology and strive to make technological breakthrough.