Abstract: Wanzhou natural gas purification plant was designed to treat high-sulfur natural gas by CPS sulfur recovery process with domestic autonomous intellectual property. So far from production, the unit has been in steady operation for more than two years. The result shows that the process design and the operation management are successful. This paper sums up the operation conditions of Wanzhou natural gas purification plant in recent years, mainly evaluates the operation conditions of desulfurization unit and sulfur-recovery unit.