Abstract: Aiming at the plugging of natural gas hydrate in the development of Sichuan and Chongqing gas field in winter, PetroChina Southwest Oil and Gasfield Company has carried on a lot of researches on the prevention and management technology of natural gas hydrate and gained some important research results and better prevention effects. Based on the present situation of the plugging of natural gas hydrate in Sichuan and Chongqing sour gas field in winter recently, this paper analyzed and summarized the main reasons of hydrate plugging, introduced the research and application development on the prevention of natural gas hydrate and management technology such as the prediction of natural gas hydrate formation in Sichuan and Chongqing oil and gas field, the development and field application of the kinetic hydrate inhibitors, and put forward the development direction.