Abstract: Based on the waste drilling fluid from PetroChina Xinjiang oilfield, a chemical destabilization agent was prepared to treat with the waste drilling fluid for gel breaking destabilization, and the pharmaceutical formulations were determined for solid-liquid separation and water treatment. A set of drilling processing equipment with belt type filter press as the core was developed, and the field application experiment was conducted in Sinopec Southwest Company and PetroChina Xinjiang oil field. Results show that the waste water can be discharged locally after meeting the related national standards, and the soaked fluid isolated from the dry mud cake can reach the related national standards, the processing cost is less than RMB 50 yuan/m³. The drilling processing technology and equipment have the advantages of simple operation and low processing cost, therefore, it has the value of application.