Abstract: Supported CaO/MgO/γ-Al₂O₃ solid base catalysts were prepared by using impregnation method. The optimal preparation conditions of catalyst which has good catalytic effect were defined as follows:the molar ratio of Ca to Mg is 4:1, calcinated at 750℃ for 12 h, and mass ratio of CaO to γ-Al₂O₃ is 18%. It was used to catalyze methyl esterification of palm oil. The results showed that the highest yield was 95.3% when the molar ratio of methanol to oil was 7:1 with addition 3.5% (wt%)CaO/MgO/γ-Al₂O₃ of oil and reacted at 60℃ for 2 h.