Abstract: Using CCUS new technology of phosphor gypsum, ammonia combined mineralizing CO₂ in tail gas of natural gas purification plant, and based on estimation of physical parameters and model establishment, the process conditions for making use of the phosphorus gypsum mineralization of CO₂ were optimized with process simulation method. It proposed the optimized reaction temperature was 60 ℃, and the reaction time was 100 minutes. Compared the simulation results of optimized process conditions with the existing technology conditions, it was concluded that the exhaust gas of CO₂, NH₃, phosphor gypsum emissions were reduced by more than 3% compared with the existing process emissions. Aimed at the optimization goal of reducing the energy consumption, the heat exchange network design of whole process can reduce the energy consumption of hot utility by 15% and that of cold utility by 5.6%, respectively.