Abstract: Aiming at the fluctuation of H₂S content in natural gas and the unqualified natural gas, the sensitivity analysis of operating parameters that affect the desulfurization device were made. The analysis result indicates that operating pressure, temperature of the absorber and MDEA circulation flow rate have little effect on H₂S content in sweet gas, but operating parameters of regenerator have a great influence on desulfurization effect. Therefore, only operating parameters of MDEA regenerator were adjusted. The results show that when the mass fraction of H₂S in natural gas increased by 58%, it can effectively reduce the content of H₂S in the sweet gas to reach the standard by slightly adjusting operating pressure and temperature of MDEA regenerator.