Abstract: Aiming at the disadvantages of poor selectivity, high production cost and environmental pollution of MDEA, it is necessary to find a kind of steric hindered amine considering the molecular structure. The steric hindered amine should be able to solve the application limitation of the existing amine desulfurization technology in natural gas purification, improve the selectivity and thus enhance the desulfurization effect of the solvent, decrease the solvent consumption, and ensure the stability of production. Based on the novel hindered amine 1, 3-two(dimethyl amine)-2-propanol (abbreviated to BDAP) for the synthesis, characterization and evaluation experiment, the results of selectivity absorption experiment showed that this kind of steric hindered amine was more effective in natural gas desulfurization. Moreover, it is simple to synthesize BDAP, easy to be separated and friendly to environment. Therefore, it has good industrial application value.