Abstract: A method of CT-LOP liquid phase redox desulfurization process was established to calculate the heat balance of the key reactor. The method was based on the principle of mass conservation and energy conservation. Physical data collected from some chemical engineer design handbooks and some commonly used chemical engineering formulas could be applied in the calculation. The results showed that the calculation data was consistent with the design data of natural gas purification plant. The method would provide technical support for the design of CT-LOP industrial equipment.