Abstract: In this paper, the design process of natural gas compressor station project was introduced by the specific design example. From all aspects of theoretical design, automatic design, safety design, equipment selection, commissioning, etc., the reasonable design, selection and prioritization scheme were proposed to bring the design to meet the requirements of environmental protection and safety. And by the actual operation data analysis, the reasonable design and operation scheme were proposed to provide the necessary reference for the design of natural gas compressor station.