Abstract: Aiming at the characteristics of low producing rate, water cut rising fast, low degree of water drive in ultra-low permeability heterogeneity reservoir, the air foam flooding is put forward, and it is necessary to study the influence factors of air foam flooding. In this paper, the influence of reservoir heterogeneity, gas liquid ratio, foam injection volume foam injection slug combination and injection time on the air foam flooding efficiency were studied experimentally. The results showed that air foam flooding could effectively produce the remaining oil in low permeability reservoir for the heterogeneous reservoir, the optimal gas and liquid ratio was 1:1, the optimal injection volume was 0.2 PV, the optimal slug size was 0.05 PV, and the optimal injection time for forming injection was when the water cut was greater than 80%. The research conclusion has a reference and guidance value for air foam flooding of heterogeneous ultra-low permeability reservoir.