Abstract: Aiming at the practical problems of conventional chemical agent used in a high salinity reservoir, having anti-salt property scarcely and improving the recovery rate difficultly, then FCI foam comprehensive exponent was uesd to screen two kinds of surface active agents TSS(12-2-12)-2OH and Triton X-100 under the conditions of high salinity reservoir. The foaming agent concentration, auxiliary foaming agent concentration and bubble foam stabilizing agent concentration were optimized. The result showed that the optimal polymer based on micro-foam flooding system was 0.2 wt% TSS(12-2-12)-2OH +0.1 wt% Triton X-100+0.15 wt% KY5S+ formation water. It supplies a new method to enhance oil recovery for high salinity reservoirs.