Abstract: Using amphoteric surfactant, gemini surfactant and non-ionic surfactant as the main agents, compounding different types of surfactants, additives and oil phases, microemulsion with low surface tension and interfacial tension has been synthesized. And the particle size, thermal stability, capacity of improving wettability, compatibility with fracturing fluid and the flowback rate were evaluated, finally the microemulsion system with excellent cleanup effect was obtained. The results indicate that the range of particle size is about 80 nm, its equilibrium value of surface tension is about 26.0 mN/m, the interfacial tension between microemulsion and kerosene is below 0.1 mN/m, which could improve the wettability of mica surface and the contact angle is improved by about 70°, so the flowback rate can be up to 29.72%. The microemulsion has thermal resistance, and the compatibility with the fracturing fluid, additives and gel breaking liquid is good.