Abstract: Since current acidizing flowback water treatment system was not well designed, the effluent could not meet the requirements and influence the operation of the joint station. In this study, based on analysis of multiple water samples, it was concluded that the acidizing flowback water was always associated with low pH, high total iron concentration, and high corrosion rate. Furthermore, combined process as "sedimentation-neutralizaiton-oxidation-coagulation/flocculation" was developed and the operation parameters were optimized to improve the treatment. The results showed that the treated water could satisfy the requirements of the joint station, with the situation that pH ranges from 6.7-7.5, total iron concentration is below 5 mg/L, corrosion rate is less than 0.076 mm/a, oil content is below 20 mg/L, and total suspended solid content is less than 20 mg/L. This study provided technical reference for acidizing flowback water treatment.