Abstract: In this paper, CFX software was used to simulate and quantitatively analyze the leakage of combustible gas in the compressor workshop of long distance pipeline. During the calculation, the medium was set as Central Asian gas and air at normal temperature and atmospheric pressure. The standard κ-ε turbulence model was adopted to calculate the leakage of combustible gas at leakage point. The results showed that the combustible gas was "inverted 7" type distribution on the top of the workshop. The area of the combustible gas with maximum concentration was located near roof when the leak point zone was excluded. This study provided a quantitative reference for combustible gas detector arrangement in the compressor workshop. Besides, the simulation demonstrated the possible accumulation points of combustible gas in the plant, and suggested the installation of ventilation point to eliminate the risks.