Abstract: In this paper, two kinds of solvents, activated MDEA and mixed amine were used to treat the acidic components H₂S and CO₂ in natural gas. Based on the different reaction mechanism of PZ and DEA with CO₂, two kinds of gas composition of high CO₂ content without H₂S and high CO₂ and H₂S content were studied. Through ASPEN HYSYS 9.0 simulation software, typical activated MDEA (PZ+MDEA) and mixed amine (DEA+MDEA) were used as absorbent to study the deacidification effect of both. The results showed that for the natural gas of high CO₂ content and non-H₂S, the activated MDEA as absorbent showed obvious energy saving advantages under the same decarburization effect and acid gas load. According to the natural gas of high CO₂ and H₂S content, using mixed amine as absorber could save more energy by the premise of achieving same decarburization effect and same acid gas load.