Abstract: For the strong water sensitivity damaging the stratum, the concentration of 3 wt% XH-F3 anti-swelling agent is selected by single factor in the low permeability reservoir. However, its anti-swelling rate is not up to the requirements of oil field. The mixture of ethanol and water injection improved the anti-swelling effect (anti-swelling rate of 92.34%) which meet the requirements of oilfield. The static experiment results show that the core breaking rate is low, the corrosion rate is also low and the compatibility is good using the anti-swelling technology. Field experiments show that the injection pressure decreased greatly, and the injection volume increased by 3-5 times after injection of the acid liquid containing anti-swelling alcohol water, so as to prevent the swelling of clay minerals and achieve the goal of removing block near the well area.