Abstract: Aiming at the problem of the conventional profile control agent which has poor effect in high temperature and high salinity reservoir of Hade oilfield, the performance evaluation and application of the intercalative gel particles control agent were taken through water swelling test, flexibility test, core flowing gradiometer test and field test. The results indicated that the intercalative gel particles can be uniformly dispersed in the solution, which has good cooperation with the formation water. The water-absorption expansion multiple of the particles is more than 5 times, and toughness factor can be more than 0.9 in formation water of Hade oilfield, Therefore the intercalative gel particles has better resistance to high temperature and high salinity. In the process of injecting the intercalative gel particles into cores with different permeability, the blocking rate of each group can reach more than 90%.The intercalative gel particles deep profile control agent was applied in Ha 4 block of Hade oilfield, which has obtained an accumulative oil increment by 17 000 t until the end of October 2018, and had good development effects.