Abstract: In order to reduce the comprehensive energy consumption of natural gas purification system and improve the purification effect, based on the gas condition of a Yanchang gas field, the natural gas purification process optimization study was developed to optimize the original data while ensuring that the purified gas met the requirements of LNG processing. Based on the process simulation of Aspen Plus, the technical and economic comprehensive comparison was carried out, and the single factor sensitivity analysis method was used to determine the parameters of regenerator such as the reflux ratio and the number of stages. The heat transfer process was analyzed using the energy saving method of the existing purification system, and the modification process was recommended. The optimization results showed that the optimized system had better purification effect, the comprehensive energy consumption was effectively reduced, and the exergy efficiency was improved by 9%.