Abstract: In order to solve the problem that gas hydrate is easy to form and block the pipeline equipment in the process of natural gas gathering and transportation, a combined hydrate inhibitor is screened by the experiment in this paper and used in the gas field to verify its safety and validity. The experimental results showed that when the inhibitor concentration was 2.0 wt%, the inhibition time was more than 1400 min. The concentration of suspended solid (SS) of treated gas field water is 4.8 mg/L, oil concentration is 15 mg/L, and pH value is less than 8. Treated water quality meets the SY/T 6596-2016 Requirement of Recommended Practice for Produced-water Reinjection in Gas Field.