Abstract: During the process of natural gas purification, the deposited sulfur generated from complexing iron desulfurization technology is easy to cause plugging of the equipment and pipeline, thus affecting the using period of desulfurization equipment. Based on the long-term follow-up studies of Sichuan CK1 Marine gas field well and YS1 well during actual production process, a series of monitoring and mitigation sulfur blockage and sulfur deposition measures were summarized by test method. Monitoring measures were mainly used to evaluate the severity of sulfur blockage and sulfur deposition by monitoring the temperature difference and pressure variation of the equipment. To slow down sulfur blockage and sulfur deposition, measures were taken to clean and sweep the internal equipment with desalted water and plant air, control desulfurization agent index and production and operation parameters, and control solution regeneration and surfactant addition, etc. Long-term follow-up tests and results showed that these measures could effectively achieve the purpose of monitoring and slowing down sulfur blockage and sulfur deposition, and prolong the running period cycle of desulfurization equipment.