Abstract: In view of the salt deposition problem in TEG dehydration system of the natural gas purification unit, which caused scaling on the solvent side of the reboiler and the water dew point rising of the product natural gas, the TEG solution component and the scale sample component were analyzed through the infrared spectrum analysis and liquid-mass spectrometry analysis etc. Combined with the actual process control situation on site, the reason of salt deposition was determined as salt compounds and organic solvents entering into the TEG system with natural gas, which caused the TEG to deteriorate and form scale. The experiment compared and selected ten kinds of solid materials. The results showed that macroporous adsorption resin D101 has a better purification effect on TEG, which can provide references for similar devices to solve similar problems.