Abstract: At present, the downhole technology of water reinjection wells in central Sichuan area can meet the requirement of produced water reinjection, but the phenomena of tube bundle break down, corrosion perforation and channeling leakage were exposed in the process of reinjection. The reinjection wells that have been shut down due to corrosion accounted for more than 35% of the shut-down wells. The corrosion evaluation result showed that the reinjection well casing in service in sulfur-containing block of central Sichuan was in moderate and serious corrosion, and the corrosion was intensified with the increase of temperature, showing local corrosion characteristics. Through the evaluation of corrosion inhibitor solubility and inhibition effect, the inhibitor CT2-19C was selected and suitable for reinjection wells in sulfur-containing blocks of central Sichuan area, the liquid-phase corrosion inhibition rate was more than 80%.