Abstract: Natural gas dehumidification plays an important role in the safe transportation and accurate measurement of natural gas. In this paper, aiming at the problems of low separation efficiency and great influence of flow pattern in the traditional gas-liquid separation device of wet gas, the gas-liquid separation method of wet gas based on rotational flow and ejector circulation technology were proposed. The separation efficiency and pressure loss characteristics under different working conditions were studied by laboratory experiments. The results showed that: (1) when the superficial gas velocity range was from 4.2 m/s to 28.5 m/s and the liquid phase volume fraction was less than 3%, the gas-liquid separation efficiency of the designed gas-liquid separation device could be basically maintained above 96% and the maximum pressure drop was 167 kPa; (2) With the increase of gas volume flow, the separation efficiency of gas-liquid separation device decreased and the pressure drop increased; (3) The wet gas volume had a little effect on separation efficiency and pressure drop. The results of this paper will provide a new way for the gas-liquid separation of wet gas in industrial production, and have important engineering significance.