Abstract: Isobutene can be selectively dimerized into diisobutene by isobutene selective oligomerization process, which can effectively utilize C₄s resources. According to the characteristics of this process, it is discussed that adding polar components such as alcohols in feeds can effectively reduce the formation of polymers and improve the selectivity of target products. It is pointed out that when TBA is used as an inhibitor, there is no ether oxides in the product, and the loss of TBA can be compensated by adding water. When the mass fraction of isobutene in the feeds is more than 25%, some measures should be taken to control the temperature rise of the reactor caused by the strong exothermic reaction, among which using the tubular reactors or adding inert components such as isooctane into the feeds are effective measures. Due to the defects of complex tower internals and tower height easily exceeding 70 m caused by the large amount of catalysts in the tower, a new type of side-reactor column configuration is proposed to replace the catalytic distillation column. This structure not only maintains the advantage of high energy utilization in catalytic distillation process, but also avoids complex structure design. The development and application of isobutene selective oligomerization process is still in its infancy in China. It is suggested to further strengthen the research on this process in order to provide a better and more powerful technical support for the effective utilization of C₄s resources in China.