Abstract: High sulfur natural gas coming from Yunan plant and Gao Fengchang gas field is treated in Wanzhou purification plant. Some surface-active substances are added to the natural gas during the exploitation of upstream gas field, which will be brought into amine solution of desulfurization unit. In addition, the temperature at the bottom of regenerator is higher than the operation temperature in other devices. The interaction between the high acidity components and other impurities will aggravate the corrosion of reboiler. All these factors could be hidden danger to the smooth running of the unit. Some equipment corrosion reasons which result in the corrosion of reboiler are analyzed elementarily and furthermore, some preventive measures were put forward for reference according to technology, equipment and operation management.