Abstract: According to the study on wax plugging problem of low-temperature separation process, a novel method of natural gas dewaxing, dehydration and dehydrocarbon was proposed, which is based on the similarity-intermiscibility theory of alcohol-hydrocarbon liquid and wax ingredients. The low-temperature alcohol-hydrocarbon liquid was injected into the feed gas to change the composition of the feed natural gas, which is beneficial for the separation of wax from the feed gas separator and lowering the separation temperature of the feed gas separator. As a result, the high separation efficiency can be obtained. Meanwhile, the injection rate of alcohol liquid could be reduced, which lead to energy reduction of the low-temperature separation system and alcohol liquid regeneration system, lowering the operating cost. It has a positive effect on energy conservation and emissions reduction, and it can also solve the problem of wax plugging in the process of low temperature separation.